The 62-year-old suggested Cheryl, 31, feels threatened by Nicole, 35, and won't allow boss Simon to reinstate her as a judge.
Louis told the Daily Star: "Why won't [Cheryl] let Nicole be on the panel this year?
"Why won't she allow Simon to have Nicole on the panel? There's your f***ing story, that's the truth. Because Nicole's good. She won't sign if Nicole signs."
Music manager Louis also hit out at Cheryl recently, labelling her as 'boring' and 'irrelevant'.
He told Heat magazine: "[She] wasn't great last year. She's sometimes lazy and lacks energy. She needs to give more, she can give so much more.
"She's irrelevant these days, I know people say the same about me […] Personally, I'd rather have Mel B on the panel. I love her – but that's not going to happen."
Cheryl replied to Louis' digs on Twitter, accusing him of being obsessed with her.
We can't wait to hear what she has to say about this…